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prmaconsulting offers best-in-class strategic and operational Pricing & Reimbursement, Market Access and Health Economics advice. We work for the majority of the top 15 Big Pharma companies, as well as in Biotech and Medtech.

Q Chip is using a novel approach to encapsulate therapeutic peptides in bioresorbable polymer microspheres for injection and sustained drug release (SR). We avoid the use of harsh solvents, high temperatures and shearing forces and achieve high API loading and microsphere monodispersity- two of the most important desirable features of any encapsulation approach, minimising production cost and enhancing syringe-ability, with controllable burst release. We have recently demonstrated successful sustained release over one month of octreotide, in a preclinical model. A small initial burst release was seen, followed by sustained and essentially zero order octreotide release over at least 35 days. Interestingly, there was no lag phase of octreotide release which might otherwise mandate additional daily injections to achieve therapeutic dosing.

We have had similar success with one and three month SR formulations of leuprolide and intend to go next to POC in man. Our octreotide and leuprolide SR formulations are available for licensing.

We use a similar benign approach to therapeutic protein encapsulation and are collaborating with Artes GmbH on the encapsulation of interferon alpha 2a for SR - targeting an improvement on the weekly shots of pegylated interferon currently taken by hep C sufferers.

Q Chip is developing novel technology platforms for the encapsulation of therapeutic peptides for sustained release (SR) and is committed to demonstrating its platforms' capabilities by producing POC data on SR depot formulations of two market leading therapeutic peptides, leuprolide and octreotide. These depot products will compete in the oncology market and in Q Chip's view represent de-risked opportunities for potential partners since both should be amenable to abbreviated regulatory procedures. We are willing to consider licensing our leuprolide and octreotide formulations and we are also interested in talking to potential partners with peptides in development - there is a clear opportunity to develop new sustained release formulations that may extend product patent life as well as enhancing patient compliance.

Through the novel application of gap analysis methods in disease biotechnology, SST develops medications that serve as biochemical prostheses that bridge broken reaction pathways, create a normal physiological environment and programme the body to build a natural resistance to the disease. Unlike conventional treatments that act to directly suppress diseases rapidly often with adverse side- effects, SST’s products are designed to gradually correct genetic faults and biochemical mistakes that underlie these diseases. 

SST has been developing a series of patented pharmaceutical and medical device technologies and has found commercial success in its product, Amzylite F1.2, the first of its many upcoming diabetic oral medications.

Sera Laboratories International Ltd (Seralab) is an independent UK company providing a fast, friendly and efficient service with a focus on quality and traceability.

Seralab is a leading supplier of control matrices and disease state material from both human and animal models. The company offers the most complete range of human and animal-based research Bioproducts in Europe. Sera Lab provides serum, plasma, whole blood, tissues, microsomes, S9 fractions and fluids from the human model and an extensive range of animal species.

Our product range also includes Cell Culture sera and reagents including FBS, Cell Specific media selected growth factors and a range of standardised reagents and tools for all areas of Stem Cell research.

The Seralab technical and managerial team have, over 20 years, established an unrivalled reputation of working closely with our customers to develop individual, tailor made solutions; often through the development of new products and techniques.

Our commitment to traditional values of quality product, competitive pricing and absolute customer care are assured through our adherence to the spirit and application of ISO9001 accreditation, which we achieved in 2010. We constantly strive for service excellence providing reliability, full traceability and extensive quality control through customer led evolution and innovation.

Founded in 1976, Simbec Research is one of Europe's premier niche contract research organisations specialising in increasingly complex early clinical studies for the international pharmaceutical and biopharmaceutical industries.

Simbec is one of Europe's foremost CROs with over 35 years' experience in clinical drug development specialising in healthy volunteer and patient volunteer studies (Phase I-IIa). Simbec is a part of the Altasciences Group which means that as well as having laboratories in South Wales, United Kingdom, it also has facilities in Quebec, Canada. Combined facilities offer over 300 beds and an extensive volunteer and patient database.

Simbec have GCP, GLP, GMP and CPA Accreditation. We also have Standard and Supplementary MHRA Accreditation, meaning that as an Investigator Centre we are able to carry out clinical trials with compounds at all levels of risk, including those that require review by an Expert Advisory Group (EAG).

Simbec Clinical Pharmacology Unit (CPU) has extensive experience in conducting and managing safety, tolerability and pharmacokinetic studies, New Chemical Entity (NCE), First into Man, Proof of Concept, radiolabelled, bioavailability and bioequivalence studies, single and multi dose and short and long term studies.

Sygnature Discovery is a leading United Kingdom-based provider of integrated drug discovery services to the global pharmaceutical industry. Key areas of expertise include medicinal and synthetic chemistry, computational chemistry and bioscience. Sygnature´s team of more than 50 industry-experienced scientists add considerable value to our clients´ programmes by undertaking key elements of the drug discovery process, such as hit finding, hit-to-lead, lead optimisation and complete integrated drug discovery projects.

Services on offer at Sygnature include:

• Medicinal Chemistry
• Synthetic Chemistry
• Computational Chemistry
• Bioscience (in vitro biology and screening)
• Arrays and Libraries
• Process and Scale-up Chemistry
• ADME/Toxicology (via a strategic alliance with Cyprotex Discovery)

Theryte is a drug discovery and development company that is committed to bringing revolutionary new cancer treatments to market.

Theryte's new approach targets the processes that normally stabilise the cancer cell, allowing the creation of novel, first-in-class anti-cancer drugs with a unique mechanism of action and efficacy against difficult-to-treat tumours.

Theryte aims to exploit its patented discoveries to: (i) develop the breakthrough technology to select pre-clinical candidates for partnering and licensing; (ii) advance a new family of anticancer targets for further drug development; and (iii) develop biomarkers to predict treatment response.