Dr Joanne McCudden
Domainex is an integrated drug discovery services company, which uses its medicinal chemistry expertise, its in silico hit screening approach and proprietary discovery technology platform, CDH, to improve efficiency in developing drug candidates.
- LeadBuilder, is a state-of-the-art virtual screening capability that identifies compounds with "lead-like" properties, ideal for progressing to drug candidates and saving 6-12 months on standard approaches.
- Combinatorial Domain Hunting (CDH), enables the fast identification of expressible (in E.coli or baculovirus) domains of drug target protein, which are able to bind ligand.
The identified protein domains are then used to quickly develop binding/activity assays for use in small molecule hit screening. This entire process only takes 4-5 months for novel drug targets and so can quickly de-rate limit exciting and challenging discovery programs. The Domainex services enhance drug discovery projects from target expression to small molecule lead optimization. Its success is illustrated by the number of drug candidates it has developed with 6 projects reaching Candidate Drug in the last 4 years (3 currently in the clinic). This success has been due to Domainex's focus on high quality, intelligence-driven drug design, supported by the expertise of its scientists.
Ms Jenny Murray
Sera Laboratories International Ltd (Seralab) is an independent UK company providing a fast, friendly and efficient service with a focus on quality and traceability.
Seralab is a leading supplier of control matrices and disease state material from both human and animal models. The company offers the most complete range of human and animal-based research Bioproducts in Europe. Sera Lab provides serum, plasma, whole blood, tissues, microsomes, S9 fractions and fluids from the human model and an extensive range of animal species.
Our product range also includes Cell Culture sera and reagents including FBS, Cell Specific media selected growth factors and a range of standardised reagents and tools for all areas of Stem Cell research.
The Seralab technical and managerial team have, over 20 years, established an unrivalled reputation of working closely with our customers to develop individual, tailor made solutions; often through the development of new products and techniques.
Our commitment to traditional values of quality product, competitive pricing and absolute customer care are assured through our adherence to the spirit and application of ISO9001 accreditation, which we achieved in 2010. We constantly strive for service excellence providing reliability, full traceability and extensive quality control through customer led evolution and innovation.